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Therapeutic Areas and Products
Cardiology

Tirofiban Premix 250 ml(in combination with heparin)is indicated for: patients with unstable angina or non-Q-wave myocardial infarction to prevent cardiac ischemic events; treatment of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy

Vernakalant hydrochloride 20mg/ml is indicated for: Rapid conversion of recent onset atrial fibrillation to sinus rhythm in adults who are hemodynamically stable

Atacand is indicated for Hypertension in patients with heart failure and impaired left ventricle systolic function ( left ventricular ejection fraction < or = 40 % ) as add-on therapy to ACE inhibitors or when ACE inhibitors are not tolerated.
Metabolic

alendronate 70mg indicated for :treatment of osteoporosis in postmenopausal women to prevent fractures, including those of the hip and spine (vertebral compression fractures); Treatment to increase bone mass in men with osteoporosis.

orlistat 120mg is indicated for :treatment of obese patients with a body mass index (BMI) greater or equal to 30 kg/m2, or overweight patients (BMI > 28 kg/m2) with associated risk factors
Blood

Phytomenadione (2mg/ml,10mg/ml)is indicated for Prophylaxis and treatment of hemorrhagic disease of the newborn

Stimofil is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. The safety and efficacy of Stimofil are similar in adults and children receiving cytotoxic chemotherapy. Stimofil is indicated for the mobilization of peripheral blood progenitor cells (PBPCs).In patients, children or adults with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of less or equal to 0.5 x 109 /L, and a history of severe or recurrent infections, long term administration of Stimofil is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events. Stimofil is indicated for the treatment of persistent neutropenia (ANC less than or equal to 1.0 x 109 /L) in patients with advanced HIV infection, in order to reduce the risk of bacterial infections when other options to manage neutropenia are inappropriate.

Crusia is indicated in adults for:•Prophylaxis of venous thromboembolic disease in moderate and high risk surgical patients, in particular those undergoing orthopaedic or general surgery including cancer surgery.•Prophylaxis of venous thromboembolic disease in medical patients with an acute illness (such as acute heart failure, respiratory insufficiency, severe infections or rheumatic diseases) and reduced mobility at increased risk of venous thromboembolism.•Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), excluding PE ikely to require thrombolytic therapy or surgery. Prevention of thrombus formation in extra corporeal circulation during haemodialysis.•Acute coronary syndrome:-Treatment of unstable angina and Non ST-segment elevation myocardial infarction (NSTEMI), in combination with oral acetylsalicylic acid.-Treatment of acute ST-segment elevation myocardial infarction (STEMI) including patients to be managed medically or with subsequent percutaneous coronary intervention (PCI)
Gynecology

10mg pyridoxine hydrochloride &10mg doxylamine succinate are indicated for : the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management.

Urofollitrophin 75 IU is indicated for :the induction of ovulation in infertile women suffering from hypothalamus or hypophyseal disorders and in spanomenorrhoeic or amenorrhoeic women

BONJESTA is indicated for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management
Antineoplastics
BMT

Busulfan 60mg/10ml is indicated as a conditioning regimen prior to hematopoietic progenitor cell transplantation
Haemato-oncology

Pegaspargase 750 IU/ml( solution for injection/infusion) is indicated for :treatment in acute lymphoblastic leukaemia (ALL) in paediatric patients from birth to 18 years, and adult patients

Tretinoin 10mg is indicated for :the induction of remission in acute promyelocytic leukemia
Oncology

Gemcitabine hydrochloride (200mg,500,mg, 1000mg)is indicated for advanced or metastatic non-small cell lung cancer and locally advanced or metastatic adenocarcinoma of the pancreas ; bladder cancer ; recurrent or metastatic breast cancer; recurrent epithelial ovarian carcinoma

Hydroxycarbamide 500 mg is indicated for : chronic myeloid leukaemia (CML); essential thrombocythemia or polycythemia vera

Decarbazine citrate (200mg,500mg,1000mg) is indicated for : metastatic malignant melanoma ; advanced Hodgkin’s disease

Oxaliplatin is indicated for: stage III (Duke‘s C) colon cancer; metastatic colorectal cancer; metastatic pancreatic adenocarcinoma
Anti inflamatory

Methotrexate (50mg/ml)is indicated for: severe psoriasis ; severe rheumatoid arthritis; severe, active juvenile idiopathic arthritis; Mild to moderate Crohn’s disease
Immunological agents

Hepatitis b immunoglobulin 312IU/ml is indicated for : the Prevention of hepatitis B recurrence following liver transplantation
NEUROLOGY
Anti infective

Ganciclovir 500mg IV is indicated for : CMV retinitis in immunocompromised patients; the prevention of CMV disease in transplant recipients

Xydalba is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI) in adults
Orphan Drugs/Rare Diseases
Tzamal Biopharma manages its orphan-drug activities through Orphan Israel – Orphan Drugs for Rare Diseases Ltd. (a registered company).